Application

D(-)-2-Amino-5-phosphonopentanoic acid has been used to pretreat BNST (bed nucleus of the stria terminalis) in order to block the induction of anxiety by ORX-A (orexin-A) into the BNST.

Biochem/physiol Actions

NMDA antagonists have muscle relaxation property and are known to offer neuron protection against brain damage induced by ischemia. 2-Amino-5-phosphonopentanoic acid has been proved to block the iontophoresis induced depolarization of NMDA.

Anticonvulsant; potent and selective N-methyl-D-aspartate (NMDA) receptor antagonist; active enantiomer of 2-amino-5-phosphonopentanoic acid.

Packaging

1, 5, 10 mg in serum bottle

assay	≥98% (TLC)
color	white
form	powder
Gene Information	mouse ... Grin2a(14811)rat ... Grik1(29559), Grin2a(24409), Grin2b(24410), Grin2c(24411), Grin2d(24412)
InChI key	VOROEQBFPPIACJ-SCSAIBSYSA-N
InChI	1S/C5H12NO5P/c6-4(5(7)8)2-1-3-12(9,10)11/h4H,1-3,6H2,(H,7,8)(H2,9,10,11)/t4-/m1/s1
mp	245-246 °C
optical purity	optical purity: ≥90% (HPLC, Marfey′s reagent)
Quality Level	100
SMILES string	N[C@H](CCCP(O)(O)=O)C(O)=O
technique(s)	ligand binding assay: suitable